Aim of the study:
Treatment nonadherence in patients with mental illnesses recurs and exacerbates the complications of the disease and disrupts the treatment process. Experienced stigma may aggravate treatment nonadherence while spiritual well-being may improve stigma and treatment adherence. This study aimed to determine the relationship of stigma with treatment adherence and spiritual well-being in patients with mental illnesses in Iran in 2019.

Subject or material and methods:
This cross-sectional correlational study was performed on patients with mental illnesses who referred to Farshchian Psychiatry Hospital of Hamadan, from December 2018 to March 2019. A total of 250 available patients were selected and asked to complete demographic, stigma, treatment adherence, and spiritual well-being questionnaires under the supervision of a researcher. Data were analyzed using descriptive statistics and path analysis in SPSS22 and AMOS23.

Results:
Mean stigma, treatment adherence, and spiritual well-being scores were calculated as 2.2±0.5, 139.89±27.52, and 83.12±19.5, respectively. The results showed a significant negative correlation between stigma and treatment adherence (r=-0.54, P<0.001). In addition, there was a significant direct relationship between treatment adherence and spiritual well-being (r=0.44, P<0.001) and a significant negative relationship between stigma and spiritual well-being (r=-0.48, P<0.001)

Discussion:
The results showed a relationship between stigma and treatment adherence, stigma and spiritual well-being, and spiritual well-being and treatment adherence.

Conclusions:
Then can be suggested that treatment teams can improve treatment adherence by undertaking several interventions to reduce stigma and promote spiritual well-being to prevent the adverse individual and social effects of treatment nonadherence