Postpartum depression (PPD) is one of the most common complications of the postpartum period. This prevalent woman's mental health problem is a serious threat to the psychological and physical well-being of both mothers and infants, and its consequences may persist in the long term. Because of the unique changes at the biological, psychological, and social levels that result from childbirth and early adaptation to motherhood, treatment of postpartum depression requires a specific approach. Although many systematic reviews describing therapeutic interventions for the treatment of PPD have appeared in the literature in recent years, the most effective therapeutic options have still not been identified. This paper reviews current treatment recommendations for postpartum depression, with consideration of their effectiveness and safety. The authors also formulate practical tips in the therapeutic management of postpartum depression, paying attention to the course and character of accompanying symptoms.