Aim. Employing an experimental, randomized-controlled design, we examined the impact of mindfulness-based cognitive therapy (MBCT) on mental health and quality of life in a sub-clinically depressed population. Method/Material. The participants were randomly assigned either to receive MBCT or remain in a waiting list control group. A series of two-way ANOVA with repeated measures detected if MBCT training would result in a decline in anxiety/depression levels, cognitive distortions, and also enhance quality life over five assessment points, namely, pre-test, session 4, session 8, first follow-up (1 month) and second follow- up (6 months). Results. The findings showed that MBCT was influential to help sub-clinical participants to deal with their anxiety and depressive feelings, and experience improved quality of life before in MBCT group, during and after stressful circumstances. Negative automatic thoughts and dysfunctional attitudes were also systematically reduced. Discussion. This study provides empirical evidence for the effectiveness of MBCT in a new cultural setting, and extends our knowledge about the effectiveness and generalizability of the MBCT in real-life stressful situations. Conclusion. The findings provide the first evidence that MBCT might be a useful intervention for enhancing quality of life in sub-clinical populations.