Aim of the study:
The aim of the present study was to investigate the effectiveness of supportive-expressive therapy on the hope and quality of life in patients with multiple sclerosis (MS).

Subject or material and methods:
This was an experimental study with pretest-posttest design together with a control group. In this regard, 32 patients from members of MS society of Tehran were selected as the sample by target sampling, and then they were placed into two groups of 16 people (experimental and control group) through random assignment. The supportive-expressive therapy was received by experimental group during twelve sessions in 75 minutes. The instruments used were Snyder et al.’s Hope Inventory and World Health Organization’s Quality of Life-Brief.

Results:
The results showed that there was a significant difference between hope and quality of life in the experimental and control groups (p<0.01).

Discussion:
Supportive-expressive therapy is effective in increasing hope and quality of life in patients with MS.

Conclusions:
The results showed that supportive-expressive therapy, with its emphasis on providing support and helping patients face and deal with their disease-related stress, can help increases hope and quality of life in patients with MS.