Aim: The aim of the study is to define selected psychological aspects of psoriasis. For analysis there are taken such factors as: stress, social stigma, cognitive processes, social support, mood, acceptance of disease and subjective assessment of life quality. Method: Two persons took part in the study. Following questionnaire methods were used: Polish version of 6-gradual scale of social sigma, E. Hrehorów, J. Szepietowski, A. Reich; Polish version of the questionnaire to assess quality of life dependent skin ailments, J. Szpietowski; General Health Questionnaire GHQ-28, D. Goldberg. The method of qualitative analysis was also used, i.e. psychobiographical method. Results: The emergence of the disease is closely associated with the experience of stress. The large surface of affected areas influences on the level of stigma, what causes worse assessment of life quality. The duration of symptoms affects the acceptance of the disease. Family support helps the tested person to think positively. When it comes to women, psoriasis does not affect noticeably on the quality of cognitive processes. In turn, taking men into account, this disease causes concentration difficulties. This person feels low social support, that the level of his mood and the assessment of life quality are strongly reduced. Conclusion: Due to the participation of psychological factors in the etiopathogenesis of psoriasis, an important part of psoriasis should become a psycho-education, and an individual psychotherapy and system psychotherapy for patient’s all family should play an important role in the treatment of the patient.