Psychotic disorders as a complication of interferon-alpha treatment of hepatitis C

Low-dose long-term interferon-a is a standard therapy for hepatitis C and is often associated with neuropsychiatric side effects, most frequently depression, mild cognitive impairment and fatigue which disappear with cessation of such treatment. Psychotic disorders are a rare complication of the treatment and usually resolve with its termination. In this paper, a review of the literature on interferon-alpha-induced psychotic disorders in hepatitis C patients has been performed. Epidemiology, predisposing factors, clinical picture, treatment and mechanisms of this serious neuropsychiatric complication have been discussed. Also, an own case of chronic schizophreniform psychosis and dementia following such treatment is described.

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eISSN:	2083-828X
ISSN:	1509-2046

The journal is supported by the State Treasury as part of the Development of Scientific Journals (RCN) program
Project no. RCN/SN/0189/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 200 000
Amount funded by the MEiN: PLN 80 000
Aims of the project: Publication in Open Access mode on the Internet of 8 consecutive issues of the journal Archives of Psychiatry and Psychotherapy (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.