In vivo stress model points (-)-α-Bisabolol as an alternative to relieve effects on neuropsychiatric disorders
1
Federal University of Ceara
2
Ceara Cancer Institute
Submission date: 2023-05-11
Final revision date: 2023-11-18
Acceptance date: 2023-11-22
Publication date: 2024-06-25
Arch Psych Psych 2024;26(2):45-57
KEYWORDS
TOPICS
PsychotherapyPsychopathology of anxiety and other „neurotic disorders”Biologic PsychiatryPharmacotherapy
ABSTRACT
Aim of the study:
The present study aimed to investigate the antidepressant and anxiolytic effect of (-)-αbisabolol (BIS) and its possible mechanisms of action related to alterations on products of oxidative stress, using the model of depression induced by Chronic Unpredictable Mild Stress
Subject or material and methods:
The male C57BL/6 mice were exposed to CUMS for 28 days, and the depressive and anxious-like behaviors was observed in the animals at the end of the protocol.
Results:
The depressive and anxious behavior was successfully attenuated after BIS administration, evidenced in forced swimming tests and preference for sucrose solution results, with exciting results when compared to Fluoxetine, the reference drug for depression.
Discussion:
The antioxidant profile as mechanism indicated a significant reduction of thiobarbituric acid reactive substances (TBARS) levels in hippocampus area.
Conclusions:
In brief, the study revealed that BIS relieve depressive and anxiety-like state through mitigating oxidative stress.
The present study aimed to investigate the antidepressant and anxiolytic effect of (-)-αbisabolol (BIS) and its possible mechanisms of action related to alterations on products of oxidative stress, using the model of depression induced by Chronic Unpredictable Mild Stress
Subject or material and methods:
The male C57BL/6 mice were exposed to CUMS for 28 days, and the depressive and anxious-like behaviors was observed in the animals at the end of the protocol.
Results:
The depressive and anxious behavior was successfully attenuated after BIS administration, evidenced in forced swimming tests and preference for sucrose solution results, with exciting results when compared to Fluoxetine, the reference drug for depression.
Discussion:
The antioxidant profile as mechanism indicated a significant reduction of thiobarbituric acid reactive substances (TBARS) levels in hippocampus area.
Conclusions:
In brief, the study revealed that BIS relieve depressive and anxiety-like state through mitigating oxidative stress.
| eISSN: | 2083-828X |
| ISSN: | 1509-2046 |
Project no. RCN/SN/0189/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 200 000
Amount funded by the MEiN: PLN 80 000
Aims of the project: Publication in Open Access mode on the Internet of 8 consecutive issues of the journal Archives of Psychiatry and Psychotherapy (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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