Detoxification of high-dose zolpidem using phenobarbital and gabapentin: two case reports

Narges Beyraghi; Alireza Shamsi; Amir Farrokhian

doi:10.12740/APP/66307

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4/2016 vol. 18

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ARTICLE

Detoxification of high-dose zolpidem using phenobarbital and gabapentin: two case reports

Narges Beyraghi ¹

Alireza Shamsi ²

Amir Farrokhian ³

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Neurosurgery and Neurofunctional research centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran

Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Department of Clinical Pharmacy, School of Pharmacy, ShahidBeheshti University of Medical Sciences, Tehran, Iran

Submission date: 2016-09-26

Final revision date: 2016-10-22

Acceptance date: 2016-10-24

Publication date: 2016-12-05

Corresponding author

Alireza Shamsi

Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Velenjak, 9185874167 Tehran, Iran

Arch Psych Psych 2016;18(4):16-19

DOI: https://doi.org/10.12740/APP/66307

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Zolpidem is a hypnotic drug from imidazopyridine family that is chemically distinct from classic benzodiazepines (BDZ). Contrary to classic BDZ, zolpidem acts selectively on α 1 subunit-containing GABA-A benzodiazepine (BZ1) receptors. There are a considerable number of zolpidem dependence case reports in the recent psychiatric literature. Regarding the similarities of zolpidem and BDZ in pharmacodynamic and addictive characteristics, writers posits that recommended detoxification protocols for short half-life BDZ, may also be useful in high doses zolpidem withdrawal symptoms management. Safety and effectiveness of phenobarbital for inpatient BDZ detoxification has been established in previous researches and it may be useful for zolpidem detoxification.

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