This study was conducted to evaluate the contribution of Psychological Immunity dimensions in predicting Psychological Flow, and the impact of two demographic factors among health workers in Kuwait. This study was performed on random sample consisted of 90 doctor and nurses were chosen from three coronavirus quarries in Kuwait. Psychological Immunity, and Psychological Flow scales were developed, validated and used current study. Psychological Immunity and psychological Flow are found to be at high levels. Furthermore, all Psychological Immunity dimensions are found to be predictors of Psychological Flow, especially optimism, and self-confidence which were found as the most important predictors. None of the demographic factors was found to be a significant predictor of the Psychological Immunity and Psychological Flow among health workers. The study suggests to stimulate awareness in health sector associations about the importance of optimism and self-confidence in protecting mental health during difficult situations.