Association study of the Brain-Derived Neurotrophic Factor (BDNF) gene C-270T polymorphism with bipolar affective disorder

Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of bipolar disorder. In this paper, the C-270T polymorphism of the BDNF gene has been studied in patients with bipolar disorder (n=380) and in the control group (n-380). Consensus diagnosis was made for each patient, according to DSM-IV, using SCID. Genotypes were determined by PCR-RFLP analysis. No association was found between the polymorphism studied and bipolar disorder. Results were also not significant when analyzed by gender and age at onset. Analysis in subgroups according to disease subtype (I and II) also did not reveal any significant differences between bipolar I and II patients and the control group.

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Association analysis of polymorphisms of the NTRK2 and BDNF genes with bipolar affective disorder in a Polish sample

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eISSN:	2083-828X
ISSN:	1509-2046

The journal is supported by the State Treasury as part of the Development of Scientific Journals (RCN) program
Project no. RCN/SN/0189/2021/1 implemented from 2022 to 2024
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Aims of the project: Publication in Open Access mode on the Internet of 8 consecutive issues of the journal Archives of Psychiatry and Psychotherapy (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.