Aim of the study:
This work considers a statistical and clinical analysis of overall morbidity, characteristics of alcohol dependence and alcohol psychosis of indigenous population in North Siberia (Yamal-Nenets Autonomous District, major gas producing region of Russia, characterized by extreme natural conditions).

Subject or material and methods:
The basic indices, which characterize the dynamics of alcohol dependence and alcohol psychosis in indigenous people of the North Siberia, are identified. As indicators of comparison, the mean age of the onset of alcohol drinking, duration of the first stage of alcoholism, alcohol tolerance, the mean age of the appearance of drinking bouts, the mean age of first and the total number of hospitalizations, and the duration of remission and variants of intoxication were used.

Results:
A more malignant course and main traits of alcohol dependence of indigenous peoples in northern Siberia, according to all investigated parameters and a 147% increase in the number patients with psychoses under monitoring of addiction specialists over the period from 2002 to 2012 were revealed.

Discussion:
Differences between indigenous people and new-comers related with specific metabolic features of natives are the background for progredient alcohol dependence. Easy access to alcohol last decades threatens to health indigenous people of the North.

Conclusions:
More severe course of alcoholism among indigenous population of North of Siberia leads to the destruction of traditional lifestyles and reduction of the indigenous population in the northern territories of the Russian Federation.